這個基因編碼的蛋白質是stat蛋白質家族的成員。作為對細胞因子和生長因子的反應，stat家族成員被受體相關激酶磷酸化，然后形成同種或異二聚體，轉移到細胞核，在那里它們作為轉錄激活劑。該蛋白通過磷酸化激活，以響應各種細胞因子和生長因子，包括IFN、EGF、IL5、IL6、HGF、LIF和BMP2。這種蛋白在細胞刺激下調節多種基因的表達，因此在許多細胞過程中起著關鍵作用，如細胞生長和凋亡。小的gtpase rac1已被證明能結合并調節這種蛋白的活性。PIAS3蛋白是這種蛋白的一種特殊抑制劑。該基因突變與嬰兒發病的多系統自身免疫性疾病和高免疫球蛋白E綜合征有關。選擇性剪接導致編碼不同亞型的多個轉錄變體。
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.