• <table id="caaaa"><source id="caaaa"></source></table>
  • <td id="caaaa"><rt id="caaaa"></rt></td>
  • <table id="caaaa"></table><noscript id="caaaa"><kbd id="caaaa"></kbd></noscript>
    <td id="caaaa"><option id="caaaa"></option></td>
  • <noscript id="caaaa"></noscript>
  • <td id="caaaa"><option id="caaaa"></option></td>
    <td id="caaaa"></td>
  • 發布時間:2022-07-13 15:50 原文鏈接: 轉化生長因子β信號通路相關的基因介紹BMPR1A基因

    骨形態發生蛋白(bmp)受體是一個跨膜絲氨酸/蘇氨酸激酶家族,包括Ⅰ型受體bmpr1a和bmpr1b和Ⅱ型受體bmpr2。這些受體還與激活素受體acvr1和acvr2密切相關。這些受體的配體是tgf-β超家族的成員。轉化生長因子β和激活素通過與兩種不同類型的絲氨酸(蘇氨酸)激酶受體形成異聚物復合物來傳遞信號:約50-55kd的Ⅰ型受體和約70-80kd的Ⅱ型受體。在沒有I型受體的情況下,II型受體結合配體,但它們需要各自的I型受體進行信號傳遞,而I型受體需要各自的II型受體進行配體結合。[由RefSeq提供,2008年7月]
    The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

    人体艺术视频