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  • 發布時間:2022-07-22 10:11 原文鏈接: 與受體酪氨酸激酶反應相關因子介紹SYK

    該基因編碼一個非受體型酪氨酸蛋白激酶家族成員。這種蛋白在造血細胞中廣泛表達,并參與將激活的免疫受體與介導多種細胞反應(包括增殖、分化和吞噬)的下游信號事件耦合。它被認為是上皮細胞生長的調節劑和潛在的腫瘤抑制因子。另外,還發現了編碼不同亞型的剪接轉錄變體。
    This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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